Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 2/20 | 0.31 |
| ▸ | GABRD | O14764 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29743252 | 1.00 | HCAR2 (0.42) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL14798042 | 1.00 | HCAR2 (0.42) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL1782927 | 0.80 | ALDH1A1 (0.35) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL1782926 | 0.80 | ALDH1A1 (0.35) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL9361035 | 0.78 | ALDH1A1 (0.33) | HCAR2TSHRKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL22129944 | 0.77 | HCAR2 (0.44) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL4928444 | 0.76 | TSHR (0.36) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL29110380 | 0.76 | HCAR2 (0.55) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL13471765 | 0.75 | DGAT1 (0.35) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL10253793 | 0.75 | HCAR2 (0.43) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185415-A1 | BRANCHED 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2019-06-20 | — | — | US | disclosed |
| US-10023528-B2 | Branched 3-phenylpropionic acid derivatives and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-17 | — | — | US | disclosed |
| US-20160264515-A1 | Branched 3-phenylpropionic acid derivatives and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-09-15 | — | — | US | disclosed |
| US-20160031908-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2016-02-04 | — | — | US | disclosed |
| US-20140309307-A1 | Branched 3-phenylpropionic acid derivatives and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-10-16 | — | — | US | disclosed |
| US-8796335-B2 | Branched 3-phenylpropionic acid derivatives and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-08-05 | — | — | US | disclosed |
| US-20130079412-A1 | Branched 3-phenylpropionic acid derivatives and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-03-28 | — | — | US | disclosed |
| US-20090281081-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264515-A1 | Branched 3-phenylpropionic acid derivatives and their use | PC, FABP3, PCCA | HCAR2 77/4885TSHR 3751/4885TP53 4341/4885 |
| US-20130079412-A1 | Branched 3-phenylpropionic acid derivatives and their use | PC, FABP3, PCCA | HCAR2 77/4885TSHR 3751/4885TP53 4341/4885 |
| US-20090281081-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | ACKR3, CCL11, CCR7 | HCAR2 71/4885TSHR 1422/4885TP53 4386/4885 |
| US-20160031908-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | ACKR3, CCR2, CXCR2 | HCAR2 69/4885TSHR 972/4885TP53 4209/4885 |
| US-20190185415-A1 | BRANCHED 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE | PC, FABP3, PCCA | HCAR2 77/4885TSHR 3751/4885TP53 4341/4885 |
| US-20140309307-A1 | Branched 3-phenylpropionic acid derivatives and their use | PC, FABP3, PCCA | HCAR2 77/4885TSHR 3751/4885TP53 4341/4885 |
| US-10023528-B2 | Branched 3-phenylpropionic acid derivatives and their use | PC, FABP3, PCCA | HCAR2 77/4885TSHR 3751/4885TP53 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.