SCHEMBL13619477

SCHEMBL13619477

COC(=O)c1ccc2nn(CCO[Si](C)(C)C(C)(C)C)nc2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.42
PTGER4 P35408 3/20 0.39
HTT P42858 2/20 0.38
ALOX15 P16050 1/20 0.38
RAB9A P51151 3/20 0.37
NPC1 O15118 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
ALDH1A1 P00352 3/20 0.37
LMNA P02545 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
FGFR1 P11362 1/20 0.36
ACSS2 Q9NR19 1/20 0.36
TLR7 Q9NYK1 1/20 0.36
JMJD6 Q6NYC1 1/20 0.36
CNR2 P34972 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12380479 0.79 KDM4E (0.52) KDM4EPTGER4HTTALOX15RAB9A
SCHEMBL31132967 0.78 HCAR3 (0.58) KDM4EHTTRAB9ANPC1SMN1; SMN2
SCHEMBL12421885 0.78 HCAR3 (0.58) KDM4EHTTRAB9ANPC1SMN1; SMN2
SCHEMBL12380477 0.78 HCAR3 (0.46) KDM4EHTTRAB9ANPC1SMN1; SMN2
SCHEMBL12421883 0.78 DUT (0.34) L3MBTL1MAPTHSD17B10
SCHEMBL2881811 0.74 KDM4E (0.51) KDM4EHTTALOX15RAB9ANPC1
SCHEMBL12709757 0.74 KDM4E (0.53) KDM4EHTTRAB9ANPC1SMN1; SMN2
SCHEMBL13125233 0.73 MET (0.56) KDM4ESMN1; SMN2ALDH1A1MAPT
SCHEMBL22748851 0.73 DUT (0.40) KDM4EHTTRAB9ANPC1SMN1; SMN2
SCHEMBL6620253 0.72 ALDH1A1 (0.49) KDM4EHTTALOX15NPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4704830-A2 MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF Septerna, Inc. (US) 2026-03-11 EP disclosed
WO-2024226914-A2 MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF SEPTERNA, INC. (US) 2024-10-31 WO disclosed
WO-2009140553-A2 HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS THRESHOLD PHARMACEUTICALS, INC. (US) 2009-11-19 WO disclosed