Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891427 | 0.76 | SCN2A (0.50) | POLBSCN2AALDH1A1KMT2AGAA | |
| SCHEMBL29025238 | 0.74 | SCN2A (0.44) | POLBSCN2ACA9ALDH1A1CA12 | |
| SCHEMBL11665539 | 0.73 | EHMT2 (0.45) | POLBSCN2ACA9ALDH1A1CA12 | |
| SCHEMBL454827 | 0.69 | POLB (0.67) | POLBCA9CA12KMT2AGAA | |
| Nitric Acid SCHEMBL11839157 | 0.67 | CASP3 (0.61) | SCN2AALDH1A1KMT2AHTTCASP3 | |
| SCHEMBL28160078 | 0.66 | POLB (0.64) | POLBCA9CA12KMT2AGAA | |
| SCHEMBL2022462 | 0.66 | POLB (0.64) | POLBCA9CA12KMT2AGAA | |
| SCHEMBL29361703 | 0.64 | ERCC1 (0.62) | POLBSCN2ACA9ALDH1A1CA12 | |
| SCHEMBL1410 | 0.64 | ERCC1 (0.62) | POLBSCN2ACA9ALDH1A1CA12 | |
| SCHEMBL710689 | 0.64 | ERCC1 (0.62) | POLBSCN2ACA9ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-04-30 | — | — | US | disclosed |
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-21 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | POLB 828/4885SCN2A 2536/4885CA9 1208/4885 |
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | HMOX2, NNMT, HMOX1 | POLB 828/4885SCN2A 2536/4885CA9 1208/4885 |
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | POLB 828/4885SCN2A 2536/4885CA9 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.