Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13619931 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TDP1CYP3A4HSD17B10MEN1 | |
| SCHEMBL2784009 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TDP1HPGDNR1H3MEN1 | |
| SCHEMBL13619903 | 0.74 | ALDH1A1 (0.43) | ALDH1A1TDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL16727258 | 0.71 | MEN1 (0.41) | ALDH1A1TDP1CYP3A4HPGDHSD17B10 | |
| Nitric Acid SCHEMBL28373917 | 0.65 | MEN1 (0.40) | ALDH1A1HPGDNR1H3MEN1KMT2A | |
| SCHEMBL15400452 | 0.64 | NPSR1 (0.39) | ALDH1A1CYP3A4HPGDNR1H3MEN1 | |
| SCHEMBL30947663 | 0.63 | ALDH1A1 (0.41) | ALDH1A1TDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL728216 | 0.63 | ALDH1A1 (0.41) | ALDH1A1TDP1CYP3A4HPGDNR1H3 | |
| SCHEMBL6911977 | 0.63 | ALDH1A1 (0.41) | ALDH1A1TDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL13619902 | 0.62 | ALDH1A1 (0.43) | ALDH1A1TDP1CYP3A4HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-04-30 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | ALDH1A1 37/4885TDP1 897/4885CYP3A4 1820/4885 |
| US-10273202-B2 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | ALDH1A1 37/4885TDP1 897/4885CYP3A4 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.