Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13619908 | 0.82 | ALDH1A1 (0.40) | ALDH1A1TSHRMAPTHSD17B10TDP1 | |
| SCHEMBL13619907 | 0.79 | MAPT (0.50) | ALDH1A1TSHRMAPTACHEHSD17B10 | |
| SCHEMBL13619905 | 0.77 | KIF11 (0.39) | ALDH1A1TSHRHSD17B10SMN1; SMN2GAA | |
| SCHEMBL11837139 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTMCOLN3ACHE | |
| SCHEMBL11837133 | 0.71 | ALDH1A1 (0.44) | ALDH1A1TSHRMAPTMCOLN3ACHE | |
| SCHEMBL11072296 | 0.67 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPTMCOLN3ACHE | |
| SCHEMBL2351631 | 0.65 | ALDH1A1 (0.48) | ALDH1A1TSHRMAPTMCOLN3ACHE | |
| SCHEMBL18595403 | 0.64 | ALDH1A1 (0.60) | ALDH1A1TSHRMAPTMCOLN3ACHE | |
| Methyl Alcohol SCHEMBL9500919 | 0.64 | ALDH1A1 (0.88) | ALDH1A1TSHRMAPTACHEHSD17B10 | |
| SCHEMBL1116059 | 0.64 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPTMCOLN3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-21 | — | — | US | disclosed |
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | THE JOHN HOPKINS UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281067-A1 | Nitroxyl progenitor compounds and methods of use | HMOX2, NNMT, HMOX1 | ALDH1A1 37/4885TSHR 4834/4885MAPT 3525/4885 |
| US-20150141378-A1 | NITROXYL PROGENITOR COMPOUNDS AND METHODS OF USE | HMOX2, NNMT, HMOX1 | ALDH1A1 37/4885TSHR 4834/4885MAPT 3525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.