SCHEMBL1362239

SCHEMBL1362239

Brc1ccc2c(c1)COC2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 9/20 0.42
ASIC3 Q9UHC3 1/20 0.42
METAP1 P53582 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
BLM P54132 1/20 0.39
ADRA2A P08913 4/20 0.38
ADRA2B P18089 3/20 0.38
ADRA2C P18825 3/20 0.38
TDP2 O95551 1/20 0.38
AHR P35869 2/20 0.37
CMA1 P23946 1/20 0.36
CHEK2 O96017 1/20 0.36
ROS1 P08922 1/20 0.36
MARK3 P27448 1/20 0.36
LTK P29376 1/20 0.36
FLT4 P35916 1/20 0.36
KDR P35968 1/20 0.36
MINK1 Q8N4C8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29417669 1.00 PNMT (0.42) PNMTASIC3METAP1LMNAMAPT
SCHEMBL204312 0.83 SRD5A1 (0.44) PNMTASIC3METAP1LMNAMAPT
SCHEMBL5366924 0.82 ASIC3 (0.46) PNMTASIC3METAP1LMNAMAPT
SCHEMBL4523516 0.82 PNMT (0.46) PNMTASIC3METAP1LMNAMAPT
SCHEMBL29790845 0.82 PNMT (0.46) PNMTASIC3METAP1LMNAMAPT
SCHEMBL8169279 0.74 METAP1 (0.44) METAP1LMNAMAPTTDP2AHR
SCHEMBL17802101 0.74 METAP1 (0.49) PNMTASIC3METAP1LMNAMAPT
SCHEMBL30016060 0.74 METAP1 (0.49) PNMTASIC3METAP1LMNAMAPT
SCHEMBL23705368 0.74 METAP1 (0.44) PNMTASIC3METAP1LMNAMAPT
SCHEMBL3174866 0.74 PARP10 (0.43) METAP1TDP2AHRCMA1CHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113122061-A Quantum dot ink and preparation method of quantum dot film TCL集团股份有限公司 2021-07-16 CN claimed
US-20260035381-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF SUMITOMO PHARMA AMERICA, INC. (US) 2026-02-05 US disclosed
EP-4667458-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER, COMPRISING SOS1 INHIBITOR AND ANTICANCER DRUG Kanaph Therapeutics Inc. (KR) 2025-12-24 EP disclosed
EP-4637754-A2 SELECTIVE BET INHIBITORS AND USES THEREOF Tay Therapeutics Limited (GB) 2025-10-29 EP disclosed
US-12435128-B2 Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1 TAIHO PHARMACEUTICAL CO., LTD. (JP) 2025-10-07 US disclosed
WO-2025049746-A1 COMPOSITIONS COMPRISING WERNER SYNDROME HELICASE INHIBITORS AND METHODS OF USING THE SAME EIKON THERAPEUTICS, INC. (US) 2025-03-06 WO disclosed
US-20240409550-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF SUMITOMO PHARMA AMERICA, INC. (US) 2024-12-12 US disclosed
US-20240400518-A1 SOS1 INHIBITOR AND USE THEREOF CYRUS THERAPEUTICS INC. (KR) 2024-12-05 US disclosed
EP-4464317-A2 COMPOUNDS AND COMPOSITIONS AND USES THEREOF Sumitomo Pharma America, Inc. (US) 2024-11-20 EP disclosed
EP-3494119-B1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF SUMITOMO PHARMA AMERICA INC (US) 2024-09-04 EP disclosed
WO-2005077927-A1 ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE JUBILANT ORGANOSYS LIMITED (IN) 2005-08-25 WO disclosed
WO-2005077891-A1 METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM H. LUNDBECK A/S (DK) 2005-08-25 WO disclosed
WO-2005066185-A1 PROCESS FOR PREPARING 5-SUBSTITUTED -1-(4-FLUOROPHENYL) -1,3-DIHYDROISOBENZOFURANS JUBILANT ORGANOSYS LIMITED (IN) 2005-07-21 WO disclosed
EP-1534654-A1 METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM H. LUNDBECK A/S (DK) 2005-06-01 EP disclosed
WO-2004020425-A1 IMPROVED PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-1-(4-­FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURANS JUBILANT ORGANOSYS LTD. (IN) 2004-03-11 WO disclosed
WO-2004014821-A1 METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM H. LUNDBECK A/S (DK) 2004-02-19 WO disclosed
CN-1468100-A pharmaceutical compositions and methods of use ���Ͽع����޹�˾ 2004-01-14 CN disclosed
CN-1452486-A pharmaceutical compositions and methods of use TARGACEPT INC (US) 2003-10-29 CN disclosed
EP-1246813-A1 METHOD FOR THE PREPARATION OF CITALOPRAM H. Lundbeck A/S (DK) 2002-10-09 EP disclosed
WO-2001049672-A1 METHOD FOR THE PREPARATION OF CITALOPRAM H. LUNDBECK A/S (DK) 2001-07-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240409550-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF CHAT, ACHE, MAOB PNMT 19/4885ASIC3 3214/4885METAP1 2239/4885
US-20260035381-A1 COMPOUNDS AND COMPOSITIONS AND USES THEREOF ADH1C, HTR6, CNR1 PNMT 436/4885ASIC3 2774/4885METAP1 1445/4885
US-12435128-B2 Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1 INMT, CARM1, KDM1B PNMT 99/4885ASIC3 3862/4885METAP1 790/4885
US-20240400518-A1 SOS1 INHIBITOR AND USE THEREOF SOS1, RAC1, SOS2 PNMT 4342/4885ASIC3 3867/4885METAP1 963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.