Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622841 | 0.84 | HTR2A (0.38) | HTR2AKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL13622797 | 0.80 | HTR2A (0.34) | HTR2AKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL13622807 | 0.78 | LMNA (0.33) | HTR2AKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL8004907 | 0.78 | HRH3 (0.36) | HTR2AKMT2AMEN1ALDH1A1HRH3 | |
| SCHEMBL13622803 | 0.77 | MEN1 (0.32) | HTR2AKMT2AMEN1ALDH1A1HRH3 | |
| SCHEMBL13622851 | 0.76 | HTR2A (0.35) | HTR2AKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL13623001 | 0.73 | — | — | |
| SCHEMBL8002704 | 0.73 | HTR6 (0.41) | HTR2AKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL13622806 | 0.72 | MEN1 (0.31) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4660967 | 0.72 | GPR119 (0.33) | KMT2AMEN1ALDH1A1POLBADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | disclosed |