Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623001 | 0.83 | — | — | |
| SCHEMBL13622767 | 0.78 | SLC6A4 (0.34) | KCNH2AGTR2 | |
| SCHEMBL8004907 | 0.77 | HRH3 (0.36) | HRH3KCNH2HTR2AMEN1KMT2A | |
| SCHEMBL13622807 | 0.77 | LMNA (0.33) | HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL8002704 | 0.72 | HTR6 (0.41) | KCNH2HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL13622805 | 0.72 | EPHX2 (0.33) | HRH3HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL13622809 | 0.72 | KMT2A (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2090738 | 0.72 | KMT2A (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL13622841 | 0.71 | HTR2A (0.38) | HRH3HTR2AMEN1KMT2AALDH1A1 | |
| SCHEMBL13478900 | 0.70 | ALDH1A1 (0.43) | HRH3MEN1KMT2AALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | disclosed |