Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563338 | 0.80 | HTR6 (0.53) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13478793 | 0.77 | PTGDR2 (0.44) | SIGMAR1HTR6 | |
| SCHEMBL14218045 | 0.75 | SIGMAR1 (0.35) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14218085 | 0.73 | HTR6 (0.40) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14624291 | 0.68 | HTR6 (0.59) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13478778 | 0.67 | PTGDR2 (0.45) | HTR6PLA2G2A | |
| SCHEMBL14623578 | 0.67 | PTGDR2 (0.45) | HTR6PLA2G2A | |
| SCHEMBL13563274 | 0.66 | HTR6 (0.57) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14218080 | 0.66 | EGFR (0.42) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL13626053 | 0.65 | HTR6 (0.46) | KDM4EMEN1KMT2AHSD17B10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140448-A1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |