Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | PARG | Q86W56 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14218045 | 0.77 | SIGMAR1 (0.35) | HTR6HRH1PARGKDM4EMEN1 | |
| SCHEMBL14624584 | 0.76 | PTGDR2 (0.40) | HTR6HRH1PARGPTGDR2 | |
| SCHEMBL16493815 | 0.74 | HRH1 (0.43) | HTR6HRH1PARGGABRA1GABRA5 | |
| SCHEMBL13625905 | 0.73 | KDM4E (0.39) | HTR6KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL14218080 | 0.73 | EGFR (0.42) | HTR6HRH1KDM4EMEN1ALDH1A1 | |
| SCHEMBL19015842 | 0.72 | HRH1 (0.55) | HTR6HRH1 | |
| SCHEMBL14217998 | 0.68 | ALDH1A1 (0.41) | HTR6HRH1PARGGABRA1GABRA5 | |
| SCHEMBL2021687 | 0.67 | SCARB1 (0.41) | HTR6HRH1PARG | |
| SCHEMBL2021685 | 0.67 | SCARB1 (0.41) | HTR6HRH1PARG | |
| SCHEMBL12579079 | 0.67 | SCARB1 (0.41) | HTR6HRH1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |