Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 10/20 | 0.40 |
| ▸ | HRH1 | P35367 | 8/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024144 | 0.85 | HRH1 (0.55) | EGFRIGF1RFLT4KDRHTR6 | |
| Hydrochloric Acid SCHEMBL2025854 | 0.84 | HTR6 (0.54) | EGFRIGF1RFLT4KDRHTR6 | |
| Hydrochloric Acid SCHEMBL2024394 | 0.84 | HTR6 (0.54) | EGFRIGF1RFLT4KDRHTR6 | |
| SCHEMBL14217998 | 0.81 | ALDH1A1 (0.41) | EGFRIGF1RFLT4KDRHTR6 | |
| SCHEMBL14217957 | 0.81 | HTR6 (0.52) | HTR6HRH1CNR2 | |
| SCHEMBL13478801 | 0.81 | HTR6 (0.55) | HTR6HRH1CNR2 | |
| SCHEMBL14218083 | 0.79 | PARG (0.36) | EGFRIGF1RFLT4KDRHTR6 | |
| SCHEMBL14218081 | 0.79 | PARG (0.38) | HTR6HRH1CNR2PLA2G2AALDH1A1 | |
| SCHEMBL14217954 | 0.78 | PRMT1 (0.39) | EGFRIGF1RFLT4KDRHTR6 | |
| SCHEMBL14218050 | 0.77 | PLA2G2A (0.41) | CNR2PLA2G2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |