SCHEMBL13625909

SCHEMBL13625909

CCCCc1nc(C)n(CCO)c(=O)c1CC1=CC=C(c2ccccc2C#N)CC1

nearest known ligand 0.45

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.34
AGTR1 P30556 1/20 0.34
APLNR P35414 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1894209 0.83 ACHE (0.44) ACHE
SCHEMBL13626516 0.81 AGTR1 (0.33) ACHEAGTR1APLNR
SCHEMBL9848891 0.77 ACHE (0.45) ACHE
SCHEMBL27771431 0.76 CYP19A1 (0.39)
SCHEMBL13625938 0.76 ALDH1A1 (0.34)
SCHEMBL13625877 0.75 APLNR (0.33) ACHEAGTR1APLNR
SCHEMBL9848919 0.75 ACHE (0.46) ACHE
SCHEMBL9848904 0.73 ACHE (0.42) ACHE
SCHEMBL1894688 0.73 GAA (0.43) ACHE
SCHEMBL14095791 0.73 AGTR1 (0.44) ACHEAGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009133970-A1 CRYSTALLINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-11-05 WO disclosed