Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626503 | 0.86 | CFTR (0.56) | CFTRMAPTF10 | |
| SCHEMBL13626533 | 0.86 | SMN1; SMN2 (0.49) | CFTRSMN1; SMN2MAPTF10 | |
| SCHEMBL13626543 | 0.82 | CFTR (0.41) | CFTRF10 | |
| SCHEMBL13626527 | 0.80 | CFTR (0.46) | CFTRMAPTF10 | |
| SCHEMBL13626532 | 0.79 | SMN1; SMN2 (0.45) | CFTRSMN1; SMN2MAPTF10 | |
| SCHEMBL8282294 | 0.75 | F10 (0.55) | MAPTF10 | |
| SCHEMBL13626501 | 0.74 | CFTR (0.59) | CFTR | |
| SCHEMBL13626492 | 0.70 | CFTR (0.55) | CFTRMAPTF10 | |
| SCHEMBL3933163 | 0.68 | CFTR (0.82) | CFTR | |
| SCHEMBL13626502 | 0.68 | LMNA (0.58) | CFTRF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |