Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CFTR | P13569 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626534 | 0.86 | CFTR (0.49) | SMN1; SMN2CFTRMAPTF10 | |
| SCHEMBL13626492 | 0.86 | CFTR (0.55) | CFTRMAPTF10 | |
| SCHEMBL13626525 | 0.81 | CFTR (0.45) | CFTRMAPTL3MBTL1TSHRALDH1A1 | |
| SCHEMBL13626532 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2CFTRMAPTTSHRPDE4B | |
| SCHEMBL13626502 | 0.76 | LMNA (0.58) | CFTRF10 | |
| SCHEMBL13626503 | 0.72 | CFTR (0.56) | CFTRMAPTF10 | |
| SCHEMBL12134285 | 0.69 | F10 (0.59) | MAPTALDH1A1F10 | |
| SCHEMBL10181196 | 0.69 | F10 (0.55) | ALDH1A1F10 | |
| SCHEMBL12134196 | 0.69 | F10 (0.57) | SMN1; SMN2F10 | |
| SCHEMBL10180964 | 0.69 | F10 (0.54) | ALDH1A1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |