Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19334515 | 0.85 | MAPT (0.50) | HTTMAPTALDH1A1IDO1LMNA | |
| SCHEMBL24709986 | 0.81 | L3MBTL1 (0.46) | TAS1R3TAS1R1ALDH1A1IDO1LMNA | |
| SCHEMBL12674141 | 0.81 | TAS1R3 (0.41) | TAS1R3TAS1R1TAS1R2HTTMAPT | |
| SCHEMBL12666642 | 0.79 | POLB (0.38) | TAS1R3TAS1R1TAS1R2MAPTALDH1A1 | |
| SCHEMBL13626615 | 0.79 | KDM4E (0.48) | HTTMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL14028554 | 0.78 | TAS1R3 (0.41) | TAS1R3TAS1R1TAS1R2MAPTALDH1A1 | |
| SCHEMBL23643056 | 0.77 | MAPT (0.47) | TAS1R3TAS1R1HTTMAPTALDH1A1 | |
| SCHEMBL632881 | 0.77 | MAPT (0.47) | TAS1R3TAS1R1TAS1R2MAPTALDH1A1 | |
| SCHEMBL14930874 | 0.72 | ALDH1A1 (0.50) | HTTMAPTALDH1A1LMNAGAA | |
| SCHEMBL11351789 | 0.71 | RAPGEF4 (0.47) | HTTMAPTALDH1A1IDO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |