Corosolic Acid

Corosolic Acid

SCHEMBL13629638

C[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(=CCC4[C@@]5(C)C[C@@H](O)[C@@H](O)C(C)(C)C5CC[C@]43C)C2[C@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 3/20 1.00
POLB P06746 3/20 1.00
PTPN2 P17706 2/20 1.00
PTPN1 P18031 2/20 1.00
PTPN6 P29350 2/20 1.00
GPBAR1 Q8TDU6 2/20 1.00
USP7 Q93009 2/20 1.00
PYGM P11217 1/20 1.00
HTT P42858 1/20 1.00
AKR1B10 O60218 2/20 0.80
AKR1B1 P15121 2/20 0.80
GABRP O00591 1/20 0.80
GABRD O14764 1/20 0.80
GABRA1 P14867 1/20 0.80
GABRB1 P18505 1/20 0.80
GABRG2 P18507 1/20 0.80
GABRB3 P28472 1/20 0.80
GABRA5 P31644 1/20 0.80
GABRA3 P34903 1/20 0.80
GABRA2 P47869 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Corosolic Acid SCHEMBL3290746 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL1280250 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL13735311 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL4456541 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL12181612 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL4962208 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL7921115 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL12740947 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL22027588 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6
Corosolic Acid SCHEMBL4456542 1.00 HSD11B1 (1.00) HSD11B1POLBPTPN2PTPN1PTPN6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7612045-B2 Compounds, compositions and methods for controlling biofilms and bacterial infections SEQUOIA SCIENCES, INC. (US) 2009-11-03 US disclosed
US-7612045-B2 Compounds, compositions and methods for controlling biofilms and bacterial infections SEQUOIA SCIENCES, INC. (US) 2009-11-03 US disclosed
US-20080145322-A1 Componds, Composition and Method for Controlling Biofolms and Bacterail Infections SEQUOIA SCIENCES, INC. 2008-06-19 US disclosed
US-20080145322-A1 Componds, Composition and Method for Controlling Biofolms and Bacterail Infections SEQUOIA SCIENCES, INC. 2008-06-19 US disclosed
US-20070014739-A1 Compositions and methods for controlling biofilms and bacterial infections SEQUOIA SCIENCES, INC. 2007-01-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080145322-A1 Componds, Composition and Method for Controlling Biofolms and Bacterail Infections CFD, SBDS, F2 HSD11B1 142/4885POLB 3771/4885PTPN2 3067/4885
US-20070014739-A1 Compositions and methods for controlling biofilms and bacterial infections RHOA, ALOX5, BLVRB HSD11B1 510/4885POLB 2669/4885PTPN2 1629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.