Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.38 |
| ▸ | CHRNG | P07510 | 4/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.38 |
| ▸ | CHRND | Q07001 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17031730 | 0.77 | KDM1A (0.46) | SLC6A3SLC6A4SLC6A2HTR2CHTR2A | |
| SCHEMBL8126583 | 0.77 | ALDH1A1 (0.39) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL10244935 | 0.75 | SLC6A4 (0.40) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL21526 | 0.74 | OPRM1 (0.45) | — | |
| SCHEMBL21524 | 0.74 | OPRM1 (0.45) | — | |
| SCHEMBL5755002 | 0.74 | OPRD1 (0.43) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL9911479 | 0.74 | SLC6A3 (0.49) | SLC6A3SLC6A4SLC6A2HTR2CHTR2A | |
| SCHEMBL23511338 | 0.73 | SLC6A4 (0.53) | SLC6A3SLC6A4SLC6A2HTR2CHTR2A | |
| SCHEMBL5754214 | 0.72 | DRD4 (0.40) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL23341010 | 0.71 | SLC6A3 (0.54) | SLC6A3SLC6A4SLC6A2HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | OPRD1, OPRK1, OPRL1 | SLC6A3 1746/4885SLC6A4 3270/4885SLC6A2 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.