Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 6/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | DNM1L | O00429 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634849 | 0.88 | GPR6 (0.41) | NPC1DNM1LPIM1CHEK1 | |
| SCHEMBL13634881 | 0.87 | NPC1 (0.40) | NPC1PIM1CHEK1 | |
| SCHEMBL13634653 | 0.86 | HRH3 (0.41) | NPC1IRAK4CHEK1 | |
| SCHEMBL13634863 | 0.83 | MAP3K7 (0.48) | IRAK4GSK3B | |
| SCHEMBL13634882 | 0.82 | MAP3K7 (0.39) | NPC1PIM1CHEK1 | |
| SCHEMBL13634880 | 0.81 | RAB9A (0.40) | NPC1MAPK1PIM1 | |
| SCHEMBL13634826 | 0.81 | GPR6 (0.39) | NPC1PIM1CHEK1 | |
| SCHEMBL13634547 | 0.80 | MAP3K7 (0.39) | IRAK4PIM1 | |
| SCHEMBL13270414 | 0.79 | UTS2R (0.38) | NPC1IRAK4CHEK1 | |
| SCHEMBL13634828 | 0.79 | RAB9A (0.41) | NPC1MAPK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |