Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 9/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786570 | 0.86 | PTGES2 (1.00) | PTGES2CA1CA2CA9 | |
| SCHEMBL7901144 | 0.76 | KMT2A (0.62) | SLC40A1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL1260477 | 0.76 | PTGES2 (0.47) | PTGES2MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL30737452 | 0.73 | ALDH1A1 (0.58) | CA12CA1CA2CA9GLO1 | |
| SCHEMBL2068236 | 0.73 | ALDH1A1 (0.58) | CA12CA1CA2CA9GLO1 | |
| SCHEMBL30737349 | 0.73 | PGR (0.62) | PTGES2ACLYSLC40A1 | |
| SCHEMBL30737455 | 0.73 | PGR (0.52) | PTGES2KMT2A | |
| Hydrochloric Acid SCHEMBL29885455 | 0.71 | ALDH1A1 (0.56) | CA1CA2CA9GLO1SLC40A1 | |
| SCHEMBL5595350 | 0.71 | DDX3X (0.71) | CA1CA2MAPTMEN1ALDH1A1 | |
| SCHEMBL13639451 | 0.71 | PTGES2 (0.77) | PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234993-B1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | ASTRAZENECA AB (SE) | 2012-11-07 | — | — | EP | disclosed |
| WO-2009082347-A1 | BIS- (SULF ONYLAMINO) DERIVATIVES FOR USE IN THERAPY | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |