Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445945 | 0.92 | NPFFR2 (0.40) | TRPA1CXCL12KMT2APOLBPKM | |
| SCHEMBL13639608 | 0.86 | NPFFR1 (0.36) | TRPA1CXCL12MAPK1CYP11B2CYP11B1 | |
| SCHEMBL12446116 | 0.84 | GRIN1 (0.43) | KMT2APOLBPKMCYP11B2MAPT | |
| SCHEMBL12446542 | 0.82 | MAOB (0.42) | PKMMAPK1SMN1; SMN2MAOB | |
| SCHEMBL13639614 | 0.80 | CXCL12 (0.34) | CXCL12CYP11B2CYP11B1SLC6A4MAOB | |
| SCHEMBL13639524 | 0.80 | DGAT1 (0.40) | FLT1FLT4KDRKMT2APOLB | |
| SCHEMBL13639667 | 0.79 | CYP11B2 (0.36) | CXCL12KMT2ACYP11B2CASP1CYP11B1 | |
| SCHEMBL2151553 | 0.78 | POLB (0.44) | TRPA1KMT2APOLBPKMMAPK1 | |
| SCHEMBL2151560 | 0.78 | POLB (0.44) | TRPA1KMT2APOLBPKMMAPK1 | |
| SCHEMBL12446099 | 0.73 | ERN1 (0.37) | CXCL12KMT2ACYP11B2CYP11B1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |