SCHEMBL1364377

SCHEMBL1364377

O=C1C[C@@H]2[C@@H](/C(O)=C\CCCc3ccccc3)[C@H](O)C[C@@H]2O1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ TK1 P04183 1/20 0.34
▸ PRKCA P17252 2/20 0.33
▸ PRKCD Q05655 2/20 0.33
▸ PRKCG P05129 1/20 0.32
▸ PRKCB P05771 1/20 0.32
▸ PRKCH P24723 1/20 0.32
▸ PRKCE Q02156 1/20 0.32
▸ PRKCQ Q04759 1/20 0.32
▸ GPR84 Q9NQS5 1/20 0.32
▸ PTGFR P43088 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8606477 0.82 ALDH1A1 (0.38) PRKCA
SCHEMBL3827791 0.81 RAB9A (0.55) RAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL8947915 0.81 PRKCA (0.38) RAB9AKDM4ENPC1SMN1; SMN2PRKCA
SCHEMBL8948021 0.81 PRKCA (0.38) RAB9AKDM4ENPC1SMN1; SMN2PRKCA
SCHEMBL5575172 0.78 RAB9A (0.64) RAB9AKDM4ENPC1SMN1; SMN2
SCHEMBL14427320 0.76 PTGER1 (0.45) RAB9AKDM4ENPC1SMN1; SMN2PRKCA
SCHEMBL10734222 0.73 GRIK1 (0.34) —
SCHEMBL15899754 0.72 FASN (0.35) SMN1; SMN2
SCHEMBL11145518 0.72 SLCO2A1 (0.42) KDM4ESMN1; SMN2PTGFR
SCHEMBL9090304 0.71 MAPT (0.43) RAB9ANPC1SMN1; SMN2PTGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110288179-A1 BIMATOPROST CRYSTALLINE FORM I FINETECH PHARMACEUTICAL LTD. (IL) 2011-11-24 — — US disclosed
US-7947740-B2 Bimatoprost crystalline form I FINETECH PHARMACEUTICAL LTD (IL) 2011-05-24 — — US disclosed
US-20090163596-A1 Bimatoprost crystalline form I FINETECH PHARMACEUTICAL LTD. (IL) 2009-06-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090163596-A1 Bimatoprost crystalline form I PTGER1, BBC3, CYP2A7 RAB9A 4172/4885KDM4E 4792/4885NPC1 3989/4885
US-20110288179-A1 BIMATOPROST CRYSTALLINE FORM I PTGER1, BBC3, CYP2A7 RAB9A 4172/4885KDM4E 4792/4885NPC1 3989/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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