Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.32 |
| ▸ | AOC1 | P19801 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19444729 | 0.87 | HRH3 (0.46) | LOXL2ALDH1A1KDM4ETGFBR1TGFBR2 | |
| SCHEMBL937666 | 0.74 | LOXL2 (0.57) | LOXL2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL13744576 | 0.74 | ALDH1A1 (0.70) | ALDH1A1KDM4EHRH3LMNA | |
| SCHEMBL17297788 | 0.74 | ALDH1A1 (0.70) | ALDH1A1KDM4EHRH3LMNA | |
| SCHEMBL17297978 | 0.74 | ALDH1A1 (0.70) | ALDH1A1KDM4EHRH3LMNA | |
| SCHEMBL14451968 | 0.72 | SLC6A2 (0.49) | ALDH1A1KDM4EAOC3POLBHRH4 | |
| SCHEMBL21674093 | 0.71 | ALDH1A1 (0.49) | ALDH1A1KDM4EAOC3HRH4HRH3 | |
| SCHEMBL21674291 | 0.68 | LOXL2 (0.49) | LOXL2ALDH1A1KDM4EHRH4KCNH3 | |
| SCHEMBL6583746 | 0.66 | KDM4E (0.78) | ALDH1A1KDM4EHRH4HRH3LMNA | |
| SCHEMBL13744480 | 0.66 | SMN1; SMN2 (0.46) | HRH3MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283238-A1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS, INC. (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283238-A1 | IRAK INHIBITORS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | LOXL2 1603/4885ALDH1A1 4076/4885KDM4E 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.