Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 2/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL937666 | 0.80 | LOXL2 (0.57) | LOXL2CHRNB2CHRNA4KCNH3KDM4E | |
| SCHEMBL18137936 | 0.75 | KDM4E (0.54) | KDM4EALDH1A1 | |
| SCHEMBL10284177 | 0.74 | LOXL2 (0.59) | LOXL2KCNH3NAMPTLATS1LATS2 | |
| SCHEMBL805499 | 0.74 | — | — | |
| SCHEMBL18137965 | 0.72 | CYP2D6 (0.50) | CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL16272259 | 0.71 | AOC1 (0.47) | CHRNB2CHRNA4PRMT6LATS1LATS2 | |
| SCHEMBL15308555 | 0.71 | KDM4E (0.51) | LOXL2CHRNB2CHRNA4PRMT6KDM4E | |
| SCHEMBL16772893 | 0.69 | CYP17A1 (0.33) | CHRNB2CHRNA4PRMT6 | |
| SCHEMBL17882255 | 0.69 | RIPK1 (0.67) | — | |
| SCHEMBL16627431 | 0.69 | CHRNB2 (0.77) | CHRNB2CHRNA4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082805-B1 | SUBSTITUTED AMINO TRIAZOLES, AND METHODS USING SAME | INST FOR DRUG DISCOVERY LLC (US) | 2020-02-05 | — | — | EP | disclosed |