Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13644118 | 0.87 | LOXL2 (0.42) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL21674093 | 0.84 | ALDH1A1 (0.49) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL937666 | 0.76 | LOXL2 (0.57) | ALDH1A1MAPTLOXL2CYP2D6SLC6A2 | |
| SCHEMBL3123680 | 0.74 | HRH3 (0.69) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL3130725 | 0.73 | KDM4E (0.72) | HRH3HRH4ALDH1A1KDM4EHTT | |
| SCHEMBL28918866 | 0.71 | ABCB11 (0.58) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL29957424 | 0.70 | ALDH1A1 (0.45) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL14451968 | 0.69 | SLC6A2 (0.49) | HRH3HRH4ALDH1A1LMNAMAPT | |
| SCHEMBL21674291 | 0.69 | LOXL2 (0.49) | HRH4ALDH1A1LOXL2KDM4E | |
| SCHEMBL11622509 | 0.69 | SLC6A2 (0.52) | HRH3HRH4ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239154-A1 | IRAK INHIBITORS AND USES THEREOF | Nimbus Iris, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-2663312-B1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS INC (US) | 2017-10-11 | — | — | EP | disclosed |