Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040415 | 0.73 | — | — | |
| SCHEMBL2309 | 0.70 | — | — | |
| SCHEMBL3128037 | 0.70 | — | — | |
| SCHEMBL7058997 | 0.67 | — | — | |
| SCHEMBL17960005 | 0.67 | — | — | |
| SCHEMBL7935312 | 0.61 | ALDH1A1 (0.36) | ALDH1A1LMNA | |
| SCHEMBL1645069 | 0.60 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL1107768 | 0.56 | — | — | |
| SCHEMBL14488948 | 0.56 | — | — | |
| SCHEMBL231828 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50634-E1 | Diaryl macrocycles as modulators of protein kinases | Turning Point Therapeutics, Inc. (US) | 2025-10-14 | — | — | US | disclosed |
| US-12404281-B2 | Diaryl macrocycles as modulators of protein kinases | Turning Point Therapeutics, Inc. (US) | 2025-09-02 | — | — | US | disclosed |
| US-20240140964-A1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-05-02 | — | — | US | disclosed |
| EP-4338739-A2 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-3636649-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-110317214-B | Diaryl macrocycles as modulators of protein kinases | 特普医药公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-110317213-B | Diaryl macrocycles as modulators of protein kinases | 特普医药公司 | 2022-10-18 | — | — | CN | disclosed |
| EP-3572416-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2022-09-21 | — | — | EP | disclosed |
| US-20220112213-A1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. | 2022-04-14 | — | — | US | disclosed |
| US-8569521-B2 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-1976843-B1 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20120264736-A1 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2012-10-18 | — | — | US | disclosed |
| US-8067621-B2 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | SCHERING CORPORATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20070197581-A1 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | MERCK SHARP & DOHME LLC | 2007-08-23 | — | — | US | disclosed |
| US-20060121069-A1 | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins | DUKE UNIVERSITY (US) | 2006-06-08 | — | — | US | disclosed |
| EP-1066254-B1 | C11 OXYMYL AND HYDROXYLAMINO PROSTAGLANDINS USEFUL AS FP AGONISTS | UNIV DUKE (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1082299-B1 | C11 OXYMYL AND HYDROXYLAMINO PROSTAGLANDINS USEFUL AS MEDICAMENTS | UNIV DUKE (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20020146439-A1 | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins | DUKE UNIVERSITY | 2002-10-10 | — | — | US | disclosed |
| US-6444840-B1 | BONE DISORDERS; VISION DEFECTS | THE PROCTER & GAMBLE CO. | 2002-09-03 | — | — | US | disclosed |
| US-6410780-B1 | BONE DISORDERS; VISION DEFECTS | THE PROCTER & GAMBLE CO. | 2002-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112213-A1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | MAP3K20, LCK, MAP3K1 | ALDH1A1 4630/4885LMNA 4097/4885 |
| US-12404281-B2 | Diaryl macrocycles as modulators of protein kinases | MAP3K20, LCK, MAP3K1 | ALDH1A1 4630/4885LMNA 4097/4885 |
| US-20240140964-A1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | MAP3K20, LCK, MAP3K1 | ALDH1A1 4630/4885LMNA 4097/4885 |
| US-20020146439-A1 | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins | PTGES, PTGS2, PTGS1 | ALDH1A1 843/4885LMNA 806/4885 |
| US-20120264736-A1 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS | BACE1, PSEN1, BACE2 | ALDH1A1 2826/4885LMNA 2290/4885 |
| US-20070197581-A1 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | BACE1, BACE2, PSEN1 | ALDH1A1 2806/4885LMNA 2368/4885 |
| US-20060121069-A1 | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins | PTGES, PTGS2, PTGS1 | ALDH1A1 843/4885LMNA 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.