Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | KDM5A | P29375 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366021 | 0.91 | DRD2 (0.52) | MAP4K4HPGDSKDM5ADRD2DRD4 | |
| SCHEMBL347402 | 0.87 | HPGDS (0.50) | HPGDSKDM5ADRD2DRD4HTR7 | |
| SCHEMBL348209 | 0.85 | HPGDS (0.56) | MAP4K4HPGDSDRD2DRD4HTR7 | |
| SCHEMBL1366139 | 0.84 | HPGDS (0.51) | HPGDSKDM5ADRD2DRD4HTR7 | |
| SCHEMBL1365756 | 0.84 | HPGDS (0.55) | MAP4K4HPGDSDRD2DRD4HTR7 | |
| SCHEMBL1365108 | 0.84 | MAP4K4 (0.50) | MAP4K4HPGDSDRD2DRD4HTR7 | |
| SCHEMBL1365697 | 0.82 | MAP4K4 (0.49) | MAP4K4HPGDSKDM5ADRD2DRD4 | |
| SCHEMBL1365865 | 0.80 | DRD2 (0.77) | HPGDSDRD2DRD4HTR7 | |
| SCHEMBL1367638 | 0.80 | USP30 (0.53) | MAP4K4HPGDSUSP30GABRA5 | |
| SCHEMBL1368210 | 0.80 | HPGDS (0.55) | MAP4K4HPGDSDRD2DRD4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067589-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | BLAKE TANISHA D | 2009-11-12 | — | — | US | disclosed |
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | BLAKE TANISHA D | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | CYP11B2, CYP11B1, LTC4S | MAP4K4 2071/4885HPGDS 99/4885KDM5A 1954/4885 |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | CYP11B2, CYP11B1, LTC4S | MAP4K4 2071/4885HPGDS 99/4885KDM5A 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.