SCHEMBL13655009

SCHEMBL13655009

C=C(N[C@H](C(=O)NO)[C@@H](C)O)c1ccc(C#Cc2ccc(NC(=O)CNCc3ccccc3OC)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ANPEP P15144 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13659653 0.93 KMT2A (0.50) KMT2AMEN1KDM4EALDH1A1SMN1; SMN2
SCHEMBL404661 0.92 KMT2A (0.49) KMT2AMEN1KDM4EALDH1A1SMN1; SMN2
SCHEMBL405405 0.89 KMT2A (0.48) KMT2AMEN1KDM4EALDH1A1SMN1; SMN2
SCHEMBL13655005 0.88 KDM4E (0.43) KMT2AMEN1KDM4E
SCHEMBL13655008 0.88 KDM4E (0.41) KDM4EALDH1A1SMN1; SMN2
SCHEMBL1109325 0.84 KMT2A (0.52) KMT2AMEN1KDM4EALDH1A1SMN1; SMN2
SCHEMBL13655015 0.84 MAPT (0.47) KDM4EANPEP
SCHEMBL13655035 0.83 HDAC1 (0.41)
SCHEMBL404237 0.83 DGAT1 (0.39) KMT2AMEN1
SCHEMBL13655030 0.83 LMNA (0.43) KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090247506-A1 Antibacterial agents CHIRON CORPORATION 2009-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247506-A1 Antibacterial agents MRPL21, SI, PGLS KMT2A 4800/4885MEN1 2414/4885KDM4E 4327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.