Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.60 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.60 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.60 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.60 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.60 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.60 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367494 | 0.89 | SLC6A12 (0.62) | POLBPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1366822 | 0.88 | DRD4 (0.60) | POLBPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1364923 | 0.86 | DGAT1 (0.53) | PRKAA1KMT2AJAK3MAPK1 | |
| SCHEMBL14094525 | 0.86 | DGAT1 (0.53) | POLBMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1366534 | 0.84 | PRKAA2 (0.75) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL1366703 | 0.84 | DGAT1 (0.55) | POLBSMN1; SMN2CYP3A4 | |
| SCHEMBL1367559 | 0.83 | DGAT1 (0.51) | DRD4CYP3A4CYP2D6 | |
| SCHEMBL4406616 | 0.83 | KDM4E (0.58) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL1364239 | 0.82 | DGAT1 (0.48) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL1367633 | 0.77 | DRD4 (0.61) | POLBPRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067589-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | BLAKE TANISHA D | 2009-11-12 | — | — | US | disclosed |
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | BLAKE TANISHA D | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | CYP11B2, CYP11B1, LTC4S | POLB 2811/4885PRKAB2 4386/4885PRKAG1 4286/4885 |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | CYP11B2, CYP11B1, LTC4S | POLB 2811/4885PRKAB2 4386/4885PRKAG1 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.