Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 4/20 | 0.62 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.61 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.61 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.61 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.61 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.61 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366388 | 0.89 | POLB (0.63) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL1367633 | 0.88 | DRD4 (0.61) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL1365085 | 0.86 | HPGDS (0.64) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL1366639 | 0.85 | SLC6A12 (0.57) | SLC6A12DRD4POLBMEN1KMT2A | |
| SCHEMBL1366750 | 0.85 | CKS1B (0.47) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL12141992 | 0.85 | KMT2A (0.51) | PRKAA1KMT2AJAK3MAPK1 | |
| SCHEMBL1366534 | 0.85 | PRKAA2 (0.75) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL1364727 | 0.82 | ADORA2A (0.49) | DRD4CYP3A4CYP2D6 | |
| SCHEMBL7239441 | 0.78 | CCR3 (0.72) | SLC6A12DRD4SIGMAR1POLBMEN1 | |
| SCHEMBL2073964 | 0.78 | PRKAA2 (0.78) | SLC6A12PRKAA2PRKAB2PRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067589-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | BLAKE TANISHA D | 2009-11-12 | — | — | US | disclosed |
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | BLAKE TANISHA D | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281125-A1 | Heterocyclic Compounds Useful in Treating Diseases and Conditions | CYP11B2, CYP11B1, LTC4S | SLC6A12 3147/4885PRKAA2 3883/4885PRKAB2 4386/4885 |
| US-20080207651-A1 | Heterocyclic compounds useful in treating diseases and conditions | CYP11B2, CYP11B1, LTC4S | SLC6A12 3147/4885PRKAA2 3883/4885PRKAB2 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.