Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PER2 | O15055 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10498437 | 0.90 | RAB9A (0.49) | KDM4EGAAMAPTGFERRAD52 | |
| SCHEMBL4711564 | 0.81 | DRD2 (0.43) | KDM4EGAAMAPTDRD2DRD3 | |
| SCHEMBL13666661 | 0.80 | LMNA (0.47) | MAPTSMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL4711615 | 0.77 | MAPT (0.44) | KDM4EGAAMAPTGFERRAD52 | |
| SCHEMBL3710958 | 0.77 | DRD2 (0.52) | DRD2DRD3RAB9AHDAC1S1PR1 | |
| SCHEMBL14734297 | 0.76 | DRD2 (0.63) | SMN1; SMN2DRD2DRD3RAB9AKMT2A | |
| SCHEMBL13179111 | 0.75 | RAB9A (0.55) | DRD2DRD3RAB9AKMT2AMEN1 | |
| SCHEMBL14734298 | 0.75 | DRD2 (0.61) | DRD2DRD3RAB9AHDAC1 | |
| SCHEMBL18937416 | 0.75 | RAB9A (0.69) | DRD2DRD3RAB9APER2KMT2A | |
| SCHEMBL31662444 | 0.75 | RAB9A (0.47) | DRD2DRD3RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119776-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |