Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PER2 | O15055 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264815 | 0.84 | DRD2 (0.41) | DRD2DRD3HDAC1RAB9APER2 | |
| SCHEMBL4710512 | 0.81 | LMNA (0.45) | DRD2DRD3ALDH1A1POLBMAPT | |
| SCHEMBL13666331 | 0.81 | KDM4E (0.45) | DRD2DRD3HDAC1DDB1CRBN | |
| SCHEMBL17080505 | 0.76 | DRD2 (0.48) | DRD2DRD3HDAC1RAB9AS1PR1 | |
| SCHEMBL17080578 | 0.76 | DRD2 (0.48) | DRD2DRD3HDAC1RAB9AS1PR1 | |
| SCHEMBL5659037 | 0.76 | DRD2 (0.65) | DRD2DRD3HDAC1RAB9AMEN1 | |
| SCHEMBL4711615 | 0.75 | MAPT (0.44) | DRD2DRD3DDB1CRBNRAB9A | |
| SCHEMBL3710958 | 0.74 | DRD2 (0.52) | DRD2DRD3HDAC1RAB9AS1PR1 | |
| SCHEMBL8471981 | 0.73 | HDAC1 (0.56) | DRD2DRD3HDAC1RAB9AS1PR1 | |
| SCHEMBL8470488 | 0.73 | HDAC1 (0.57) | DRD2DRD3HDAC1RAB9AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-B1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1824844-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2007-08-29 | — | — | EP | disclosed |
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | BAYER HEALTHCARE AG (DE) | 2006-12-21 | — | — | US | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006061116-A1 | PYRAZINE DICARBOXAMIDES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287315-A1 | Pyrazinedicarboxamides and their use | PEPD, AADAC, PYCARD | DRD2 1659/4885DRD3 1634/4885HDAC1 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.