SCHEMBL1367261

SCHEMBL1367261

O=CCSc1ccccc1CF

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
APOBEC3G Q9HC16 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1366042 0.81 APOBEC3G (0.31) APOBEC3G
SCHEMBL249080 0.76 MEN1 (0.41) MEN1KMT2A
SCHEMBL11172021 0.75 MEN1 (0.43) MEN1KMT2AAPOBEC3G
SCHEMBL2558474 0.72 MCHR1 (0.42) MEN1KMT2A
SCHEMBL28048096 0.72 RAB9A (0.42) MEN1KMT2A
SCHEMBL10509688 0.68 MTNR1A (0.50) MEN1KMT2A
SCHEMBL11954594 0.68 CYP1A2 (0.62) MEN1KMT2A
SCHEMBL22650245 0.68 KMT2A (0.37) MEN1KMT2A
SCHEMBL946878 0.66 ALDH1A1 (0.52)
SCHEMBL7523014 0.65 APOBEC3G (0.35) APOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130101509-A1 IMAGING AND RADIOTHERAPY METHODS GENERAL ELECTRIC COMPANY (US) 2013-04-25 US disclosed
WO-2013048811-A1 IMAGING AND RADIOTHERAPY METHODS FOR TUMOUR STEM CELLS GE HEALTHCARE LIMITED (GB) 2013-04-04 WO disclosed
WO-2013048832-A1 18 F - LABELLED 6 - ( 2 - FLUOROETHOXY) - 2 - NAPHTHALDEHYDE FOR DETECTING CANCER STEM CELLS GE HEALTHCARE LIMITED (GB) 2013-04-04 WO disclosed
US-20110286922-A1 IMAGING AND RADIOTHERAPY METHODS GENERAL ELECTRIC COMPANY 2011-11-24 US disclosed
EP-2349351-A2 IMAGING AND RADIOTHERAPY METHODS GE Healthcare Limited (GB) 2011-08-03 EP disclosed
WO-2010048144-A2 IMAGING AND RADIOTHERAPY METHODS GE HEALTHCARE LIMITED (GB) 2010-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130101509-A1 IMAGING AND RADIOTHERAPY METHODS ALDH2, ALDH3A1, ALDH1A1 MEN1 2884/4885KMT2A 1972/4885APOBEC3G 343/4885
US-20110286922-A1 IMAGING AND RADIOTHERAPY METHODS ALDH2, ALDH3A1, ALDH1A1 MEN1 2884/4885KMT2A 1972/4885APOBEC3G 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.