Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL366434 | 0.81 | USP30 (0.33) | DGAT1 | |
| Bicarbonate SCHEMBL2872040 | 0.78 | PDGFRB (0.42) | F2F11PRSS1PRSS2PRSS3 | |
| SCHEMBL1114281 | 0.77 | RXFP1 (0.33) | UCHL1PDGFRBKDR | |
| SCHEMBL13674698 | 0.77 | PDGFRB (0.33) | F2F11PRSS1PRSS2PRSS3 | |
| SCHEMBL30831491 | 0.75 | F11 (0.35) | F2F11PRSS1PRSS2PRSS3 | |
| SCHEMBL14745854 | 0.75 | F11 (0.35) | F2F11PRSS1PRSS2PRSS3 | |
| SCHEMBL14745971 | 0.74 | UCHL1 (0.33) | F2F11PRSS1PRSS2PRSS3 | |
| SCHEMBL17841389 | 0.74 | LPL (0.31) | — | |
| SCHEMBL14745974 | 0.72 | KDM4E (0.38) | F2F11PRSS1PRSS2PRSS3 | |
| Formamide SCHEMBL28514935 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336132-B1 | MORPHOLINOPURINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2014-01-01 | — | — | EP | disclosed |
| US-8309546-B2 | Morpholinopurine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-11-13 | — | — | US | disclosed |