Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20519911 | 0.78 | NNMT (0.37) | NNMTF11F2PRSS1PRSS2 | |
| SCHEMBL1710489 | 0.75 | DGAT1 (0.35) | NNMTF11F2PRSS1PRSS2 | |
| SCHEMBL23795678 | 0.74 | UCHL1 (0.35) | KDM4ESMN1; SMN2UCHL1L3MBTL1 | |
| SCHEMBL28628579 | 0.74 | SMN1; SMN2 (0.62) | KDM4ESMN1; SMN2NNMTPARP1L3MBTL1 | |
| SCHEMBL21199613 | 0.73 | GAA (0.45) | KDM4ESMN1; SMN2UCHL1L3MBTL1 | |
| SCHEMBL14745854 | 0.73 | F11 (0.35) | PARP1F11F2PRSS1PRSS2 | |
| SCHEMBL30831491 | 0.73 | F11 (0.35) | PARP1F11F2PRSS1PRSS2 | |
| SCHEMBL16599604 | 0.73 | KDM4E (0.33) | KDM4EF11F2PRSS1PRSS2 | |
| Bicarbonate SCHEMBL13674697 | 0.72 | F2 (0.33) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2825036 | 0.72 | F11 (0.36) | NNMTPARP1F11F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |