Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30831491 | 1.00 | F11 (0.35) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16599602 | 0.86 | UCHL1 (0.34) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16238349 | 0.81 | F11 (0.36) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14745971 | 0.81 | UCHL1 (0.33) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28504523 | 0.81 | USP30 (0.34) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18302169 | 0.76 | PDGFRB (0.34) | PDGFRBKDR | |
| Bicarbonate SCHEMBL13674697 | 0.75 | F2 (0.33) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL14746300 | 0.75 | PDGFRB (0.45) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19744093 | 0.75 | SIRT6 (0.37) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28811788 | 0.74 | DGAT1 (0.34) | UCHL1DGAT1LIPEUSP30ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117157299-B | Tricyclic heterocyclic derivative, composition and application thereof | 北京丹擎医药科技有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| CN-107207508-B | 9H-pyrrolo-bipyridine derivatives | UCB生物制药私人有限公司 | 2020-02-28 | — | — | CN | disclosed |
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |