Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14745854 | 0.81 | F11 (0.35) | UCHL1F11F2PRSS1PRSS2 | |
| SCHEMBL30831491 | 0.81 | F11 (0.35) | UCHL1F11F2PRSS1PRSS2 | |
| SCHEMBL29843434 | 0.79 | DGAT1 (0.34) | UCHL1DGAT1KMT2ALIPEUSP30 | |
| SCHEMBL28811788 | 0.79 | DGAT1 (0.34) | UCHL1DGAT1KMT2ALIPEUSP30 | |
| SCHEMBL14746448 | 0.76 | KDM4E (0.31) | KDM4EKMT2A | |
| Bicarbonate SCHEMBL13674697 | 0.74 | F2 (0.33) | UCHL1F11F2PRSS1PRSS2 | |
| SCHEMBL19744093 | 0.73 | SIRT6 (0.37) | UCHL1F11F2PRSS1PRSS2 | |
| SCHEMBL3627380 | 0.73 | CA1 (0.36) | — | |
| SCHEMBL3450364 | 0.73 | UCHL1 (0.38) | UCHL1DGAT1POLBLIPEUSP30 | |
| SCHEMBL16599602 | 0.73 | UCHL1 (0.34) | UCHL1F11F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |