Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GGT1 | P19440 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320510 | 0.86 | LMNA (0.56) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL18224473 | 0.86 | HCRTR1 (0.57) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL28136228 | 0.82 | SLC6A3 (0.57) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL27537998 | 0.82 | LMNA (0.57) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7926507 | 0.82 | ALDH1A1 (0.51) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL11201342 | 0.81 | LMNA (0.66) | KDM4ELMNAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL7172322 | 0.80 | HPGD (0.54) | KDM4ELMNAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL14972 | 0.80 | HSD17B10 (0.69) | KDM4ELMNAALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL2352850 | 0.80 | HTT (0.50) | KDM4ELMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL2778 | 0.79 | TSHR (0.52) | KDM4ELMNAALDH1A1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331528-B1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | MERCK SHARP & DOHME (US) | 2020-05-27 | — | — | EP | disclosed |
| US-8859529-B2 | Compounds for the treatment of inflammatory disorders | MERCK SHARP & DOHME CORP. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20110288054-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2331528-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Schering Corporation (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010036638-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288054-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | ADAMTS1, ADAMTS13, ADAMTS7 | KDM4E 4257/4885LMNA 792/4885ALDH1A1 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.