Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601700 | 0.82 | L3MBTL1 (0.44) | HSD17B1HSD17B2KDRAR | |
| SCHEMBL12498936 | 0.81 | HSD17B1 (0.67) | HSD17B1HSD17B2KDRKITGAK | |
| SCHEMBL23601702 | 0.80 | HSD17B1 (0.42) | HSD17B1HSD17B2KDRARPTPN5 | |
| SCHEMBL23601917 | 0.78 | PIK3CD (0.50) | HSD17B1HSD17B2KDRFGFR1MAP4K4 | |
| SCHEMBL13036072 | 0.76 | AR (0.48) | ARPTPN5 | |
| SCHEMBL5544105 | 0.76 | SCN5A (0.48) | ARPTPN5PDK2ENPP3MEN1 | |
| SCHEMBL30376921 | 0.75 | DGAT1 (0.40) | HSD17B1HSD17B2KDRCTSDBACE1 | |
| SCHEMBL13680477 | 0.75 | CYP2A6 (0.46) | SCN10A | |
| SCHEMBL7996271 | 0.75 | CCR1 (0.43) | MEN1KMT2A | |
| SCHEMBL21377212 | 0.74 | AR (0.42) | ARPTPN5PDK2MAP4K4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |