Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680472 | 0.81 | CCR1 (0.52) | GRM5NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2346786 | 0.81 | RARA (0.55) | GRM5NPC1RAB9ASMN1; SMN2CCR1 | |
| SCHEMBL13680471 | 0.81 | TDP1 (0.50) | GRM5NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL29949633 | 0.80 | TGFBR1 (0.50) | GRM5MKNK2MKNK1TGFBR1CCR1 | |
| SCHEMBL12270020 | 0.80 | TGFBR1 (0.50) | GRM5MKNK2MKNK1TGFBR1CCR1 | |
| Hydrochloric Acid SCHEMBL3088531 | 0.80 | RARA (0.54) | GRM5NPC1RAB9ASMN1; SMN2CCR1 | |
| SCHEMBL3422361 | 0.78 | CCR1 (0.75) | RAB9AMAPTMEN1KMT2ATGFBR1 | |
| SCHEMBL13680553 | 0.78 | GBA1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680473 | 0.77 | TGFBR1 (0.48) | GRM5SMN1; SMN2MEN1KMT2ATGFBR1 | |
| SCHEMBL13680474 | 0.77 | ALDH1A1 (0.55) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |