Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.43 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680645 | 0.83 | HSD17B2 (0.51) | HSD17B1HSD17B2DHODHMAPTPOLB | |
| SCHEMBL12394209 | 0.81 | DHODH (0.64) | HSD17B1HSD17B2DHODHMAPTPOLB | |
| SCHEMBL13681333 | 0.81 | HSD17B2 (0.50) | HSD17B1HSD17B2DHODHMAPTPOLB | |
| SCHEMBL18155128 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1 | |
| SCHEMBL6561397 | 0.79 | ACHE (0.61) | HSD17B1HSD17B2POLBRAB9AENPP3 | |
| SCHEMBL13680640 | 0.79 | HSD17B2 (0.48) | HSD17B1HSD17B2DHODHMAPTPOLB | |
| SCHEMBL13680639 | 0.79 | HSD17B2 (0.55) | HSD17B1HSD17B2DHODHMAPTPOLB | |
| SCHEMBL1435772 | 0.78 | PARP1 (0.63) | MAPTCYP1A2PARP1ALDH1A1GAA | |
| SCHEMBL6697507 | 0.78 | WDR5 (0.60) | MAPTCTDSP1RAB9AALDH1A1 | |
| SCHEMBL13680643 | 0.77 | CYP1A2 (0.67) | MAPTCYP1A2CSF1RFLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |