Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680716 | 0.85 | MAPT (0.39) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680713 | 0.79 | GSK3B (0.41) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680700 | 0.78 | MAP4K4 (0.41) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680461 | 0.76 | SMN1; SMN2 (0.60) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13681019 | 0.76 | ALDH1A1 (0.36) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL13680715 | 0.74 | TDP1 (0.42) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13304496 | 0.72 | ADORA3 (0.46) | KDM4EALDH1A1MAPTADORA3ADORA1 | |
| SCHEMBL17214835 | 0.71 | NQO2 (0.76) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680711 | 0.71 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL13680718 | 0.71 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |