Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 9/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680488 | 0.85 | KIF11 (0.59) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13680510 | 0.83 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13680486 | 0.83 | MAPT (0.52) | SMN1; SMN2HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL13680492 | 0.82 | TSHR (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11806777 | 0.81 | MEN1 (0.63) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL17214835 | 0.81 | NQO2 (0.76) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11457930 | 0.80 | MEN1 (0.61) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL11806724 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL3029028 | 0.79 | KDM4E (0.58) | SMN1; SMN2HTTL3MBTL1MEN1KMT2A | |
| SCHEMBL13680490 | 0.79 | PSMB8 (0.54) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |