Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680797 | 0.82 | CYP11B2 (0.38) | GRIN1GRIN2BCDK8 | |
| SCHEMBL13680798 | 0.81 | CYP1A2 (0.38) | GRIN1GRIN2BMRGPRX4 | |
| SCHEMBL13680808 | 0.80 | EPHX2 (0.38) | GRIN1GRIN2BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL18233495 | 0.79 | SYK (0.53) | GRIN1GRIN2BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13680787 | 0.79 | AGXT (0.56) | — | |
| SCHEMBL4010033 | 0.78 | DAO (0.50) | GRIN1GRIN2BMRGPRX4 | |
| SCHEMBL18003547 | 0.77 | MAOB (0.50) | — | |
| SCHEMBL13680810 | 0.76 | HSD17B1 (0.53) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13680811 | 0.76 | HIF1A (0.48) | — | |
| SCHEMBL13680850 | 0.76 | TRPV3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |