Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 8/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680956 | 0.83 | SHMT2 (0.40) | SHMT2PIM1TP53KDM4EALDH1A1 | |
| SCHEMBL4905450 | 0.83 | SHMT2 (0.56) | SHMT2PIM1SCN10AAVPR1BTP53 | |
| SCHEMBL27755468 | 0.83 | SHMT2 (0.56) | SHMT2PIM1SCN10AAVPR1BTP53 | |
| SCHEMBL13680929 | 0.83 | ALDH1A1 (0.62) | TP53KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL13680930 | 0.83 | LMNA (0.55) | PIM1TP53KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2088997 | 0.82 | SHMT2 (0.61) | SHMT2PIM1SCN10AAVPR1BTP53 | |
| SCHEMBL2705784 | 0.80 | KDM4E (0.65) | SHMT2PIM1SCN10AAVPR1BADORA1 | |
| SCHEMBL4774884 | 0.80 | SHMT2 (0.61) | SHMT2PIM1SCN10AAVPR1BTP53 | |
| SCHEMBL4777890 | 0.80 | SHMT2 (0.58) | SHMT2PIM1SCN10AAVPR1BTP53 | |
| SCHEMBL13680957 | 0.79 | KDM4E (0.50) | TP53KDM4EALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |