Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680959 | 0.84 | CYP19A1 (0.53) | CYP19A1PPARDPPARALMNAMAPT | |
| SCHEMBL13680931 | 0.83 | SHMT2 (0.56) | SHMT2PIM1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13680952 | 0.82 | CPT1A (0.41) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680950 | 0.81 | PPARD (0.40) | CYP19A1PPARDPPARALMNAMAPT | |
| SCHEMBL13680953 | 0.80 | LMNA (0.41) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680845 | 0.79 | SCN9A (0.41) | ALDH1A1L3MBTL1POLB | |
| SCHEMBL13680955 | 0.78 | GAA (0.42) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680930 | 0.76 | LMNA (0.55) | LMNAPIM1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13680954 | 0.76 | KDM4E (0.40) | LMNAPIM1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL13680493 | 0.75 | CYP2A6 (0.47) | SHMT2CYP19A1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |