Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 13/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680931 | 0.83 | SHMT2 (0.56) | MAPTKDM4ESMN1; SMN2TP53PIM1 | |
| SCHEMBL27720173 | 0.82 | LMNA (0.56) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680952 | 0.82 | CPT1A (0.41) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL4905756 | 0.81 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680926 | 0.81 | LMNA (0.56) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL27912402 | 0.81 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL3370362 | 0.81 | LMNA (0.58) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680943 | 0.81 | RAB9A (0.48) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL13680922 | 0.81 | GFER (0.62) | LMNAMAPTKDM4ESMN1; SMN2TP53 | |
| SCHEMBL6343767 | 0.81 | LMNA (0.55) | LMNAMAPTKDM4ESMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |