Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680904 | 0.82 | NPC1 (0.45) | CA12CA9MAPTCA1NPC1 | |
| SCHEMBL13680976 | 0.80 | MAPT (0.50) | MAPTGAATHRBTP53PKM | |
| SCHEMBL13681029 | 0.77 | ALDH1A1 (0.36) | MAPTPKMPOLBALDH1A1KDM4E | |
| SCHEMBL13680975 | 0.75 | PDE3B (0.48) | MAPTGAATHRBTP53PKM | |
| SCHEMBL13680599 | 0.75 | CA12 (0.54) | CA12CA9F11ARMAPT | |
| SCHEMBL13681003 | 0.74 | HRH3 (0.39) | CA12CA9F11ARMAPT | |
| SCHEMBL13680856 | 0.72 | CA12 (0.38) | CA12CA9F11ARTHRB | |
| SCHEMBL13680972 | 0.72 | ALDH1A1 (0.45) | MAPTGAATP53NPC1PKM | |
| SCHEMBL13680887 | 0.70 | ALDH1A1 (0.46) | MAPTPKMPOLBALDH1A1KDM4E | |
| SCHEMBL13680864 | 0.70 | ALDH1A1 (0.63) | MAPTTHRBNPC1PKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |