Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | GAA | P10253 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680975 | 0.81 | PDE3B (0.48) | MAPTGAATP53THRBLMNA | |
| SCHEMBL13680977 | 0.80 | CA12 (0.40) | MAPTGAATP53THRBPDE3B | |
| SCHEMBL13680904 | 0.77 | NPC1 (0.45) | MAPT | |
| SCHEMBL13680972 | 0.76 | ALDH1A1 (0.45) | MAPTGAATP53LMNATERT | |
| SCHEMBL13680971 | 0.75 | TERT (0.44) | MAPTTP53TERTALDH1A1HPGD | |
| SCHEMBL13681029 | 0.74 | ALDH1A1 (0.36) | MAPTLMNAPKMALDH1A1NPSR1 | |
| SCHEMBL13680864 | 0.73 | ALDH1A1 (0.63) | MAPTTHRBPKMALDH1A1NPSR1 | |
| SCHEMBL13680866 | 0.73 | ALDH1A1 (0.60) | MAPTTP53THRBLMNAPKM | |
| SCHEMBL13680887 | 0.73 | ALDH1A1 (0.46) | MAPTLMNAPKMALDH1A1NPSR1 | |
| SCHEMBL13680595 | 0.73 | GRIA1 (0.53) | MAPTGAATP53THRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |