Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | NOS3 | P29474 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OGT | O15294 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680976 | 0.81 | MAPT (0.50) | PDE3BPDE3ANPSR1TSHRLMNA | |
| SCHEMBL13680991 | 0.76 | PDE3B (0.48) | PDE3BPDE3ANOS1NOS3NOS2 | |
| SCHEMBL13680971 | 0.75 | TERT (0.44) | MAPTTP53ALDH1A1KDM4EHPGD | |
| SCHEMBL13680977 | 0.75 | CA12 (0.40) | PDE3BPDE3ANPSR1CYP1A2TSHR | |
| SCHEMBL13680594 | 0.75 | NOS1 (0.58) | PDE3BPDE3ANOS1NOS3NOS2 | |
| SCHEMBL13680972 | 0.73 | ALDH1A1 (0.45) | PDE3BPDE3ACYP1A2LMNABLM | |
| SCHEMBL13681029 | 0.72 | ALDH1A1 (0.36) | NPSR1CYP1A2TSHRLMNAPOLB | |
| SCHEMBL13680904 | 0.72 | NPC1 (0.45) | MAPT | |
| SCHEMBL13680864 | 0.71 | ALDH1A1 (0.63) | NPSR1CYP1A2TSHRPOLBMAPT | |
| SCHEMBL13680887 | 0.71 | ALDH1A1 (0.46) | NPSR1CYP1A2TSHRLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |