Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680973 | 0.90 | CRBN (0.42) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL13680968 | 0.76 | ALDH1A1 (0.35) | CYP1A2MAOB | |
| SCHEMBL13680600 | 0.76 | GRIA1 (0.57) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL16090326 | 0.76 | PGR (0.57) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL23222381 | 0.76 | HRH1 (0.51) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL13680969 | 0.75 | GSK3B (0.43) | — | |
| SCHEMBL13681010 | 0.75 | PDE3B (0.50) | PDE3BPDE3APGRGRIA1CACNG8 | |
| SCHEMBL13681001 | 0.74 | HSD17B1 (0.44) | PGRCYP1A2CYP11B1CYP11B2MAOB | |
| SCHEMBL13680985 | 0.73 | PRF1 (0.52) | — | |
| SCHEMBL13680976 | 0.71 | MAPT (0.50) | PDE3BPDE3AGRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |